Peter Brouckaert Selected Research

Soluble Guanylyl Cyclase

10/2017	Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.
1/2017	Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice.
1/2017	Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice.
1/2016	Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.
10/2015	Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
6/2015	Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation.
3/2014	Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.
10/2013	The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease.
4/2013	Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma.
1/2013	The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.

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Peter Brouckaert Research Topics

Disease

12	Shock 10/2015 - 04/2003
7	Neoplasms (Cancer) 01/2020 - 04/2004
7	Sepsis (Septicemia) 12/2016 - 04/2003
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 07/2009
6	Hypotension (Low Blood Pressure) 01/2014 - 08/2006
6	Septic Shock (Toxic Shock Syndrome) 01/2014 - 04/2003
5	Infarction (Infarctions) 01/2019 - 12/2009
5	Hypothermia 10/2013 - 12/2009
4	Necrosis 10/2015 - 05/2002
4	Reperfusion Injury 10/2011 - 12/2009
4	Ischemia 06/2011 - 12/2009
3	Endotoxemia 11/2021 - 11/2006
3	Myocardial Infarction 01/2019 - 03/2011
3	Erectile Dysfunction 01/2017 - 02/2015
3	Hypertension (High Blood Pressure) 01/2016 - 07/2008
2	Left Ventricular Dysfunction 01/2017 - 10/2011
2	Inflammation (Inflammations) 06/2015 - 01/2006
2	Asthma (Bronchial Asthma) 06/2015 - 10/2013
2	Chronic Obstructive Pulmonary Disease (COPD) 06/2015 - 10/2013
2	Acute Lung Injury 06/2015 - 10/2013
2	Chronic Renal Insufficiency 01/2015 - 07/2009
2	Open-Angle Glaucoma (Glaucoma, Open Angle) 04/2013 - 01/2013
2	Body Weight (Weight, Body) 09/2012 - 02/2004
2	Hypoxia (Hypoxemia) 08/2007 - 01/2006
1	Hypertrophy 12/2017
1	Cardiac Arrhythmias (Arrythmia) 12/2017
1	Fatigue 10/2017
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 10/2017
1	Type 2 Diabetes Mellitus (MODY) 01/2017
1	Glaucoma 01/2017
1	Cardiotoxicity 01/2017
1	Cardiomyopathies (Cardiomyopathy) 12/2016
1	HIV Infections (HIV Infection) 12/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2016
1	Sickle Cell Anemia (Hemoglobin S Disease) 06/2015
1	Lung Injury 06/2015
1	Hepatitis 09/2014
1	Esophageal Achalasia (Megaesophagus) 03/2014
1	Pneumonia (Pneumonitis) 10/2013

Drug/Important Bio-Agent (IBA)

19	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2017 - 06/2007
19	Soluble Guanylyl CyclaseIBA 10/2017 - 08/2006
11	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 04/2003
7	Vasodilator Agents (Vasodilators)IBA 02/2015 - 08/2006
6	CytokinesIBA 01/2014 - 04/2003
6	LipopolysaccharidesIBA 10/2013 - 02/2004
5	Nitric Oxide Synthase (NO Synthase)IBA 11/2021 - 06/2007
4	BAY 58-2667IBA 01/2017 - 01/2013
3	EnzymesIBA 01/2017 - 04/2011
3	Proteins (Proteins, Gene)FDA Link 06/2015 - 03/2011
3	AntioxidantsIBA 02/2015 - 06/2007
2	Arginine (L-Arginine)FDA Link 11/2021 - 06/2015
2	Interferon-gamma (Interferon, gamma)IBA 01/2020 - 02/2004
2	Pharmaceutical PreparationsIBA 01/2019 - 04/2004
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 10/2017 - 06/2015
2	Heme (Haem)IBA 01/2017 - 10/2015
2	AcidsIBA 01/2017 - 09/2010
2	CalciumIBA 12/2016 - 05/2008
2	EndotoxinsIBA 06/2015 - 08/2009
2	Protein Kinases (Protein Kinase)IBA 09/2014 - 06/2011
2	Interleukin-6 (Interleukin 6)IBA 01/2013 - 11/2006
2	NitritesIBA 02/2011 - 12/2009
2	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)IBA 09/2010 - 05/2008
2	Biological ProductsIBA 12/2009 - 07/2009
2	CaspasesIBA 06/2007 - 04/2003
1	CitrullineIBA 11/2021
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2021
1	Amino Acids FDA Link 11/2021
1	Interferon Type IIBA 01/2020
1	Tumor Biomarkers (Tumor Markers)IBA 01/2020
1	Cyclophilins (Cyclophilin)IBA 01/2019
1	Angiotensin IIIBA 12/2017
1	Connexin 43 (Connexin43)IBA 12/2017
1	Adenosine Triphosphate (ATP)IBA 10/2017
1	Focal Adhesion Kinase 2IBA 07/2017
1	Coffee FDA Link 01/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Doxycycline (Periostat)FDA LinkGeneric 01/2017
1	ferulic acid (sodium ferulate)IBA 01/2017
1	HLA-C Antigens (HLA-C)IBA 12/2016
1	AndrogensIBA 01/2016
1	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2016
1	ARGX-111IBA 08/2015
1	AntibodiesIBA 08/2015
1	LigandsIBA 08/2015
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 08/2015
1	Cytostatic AgentsIBA 08/2015
1	ArginaseIBA 06/2015
1	sodium bisulfide (NaHS)IBA 06/2015
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 06/2015
1	OximesIBA 04/2015
1	GalactosamineIBA 09/2014
1	Immune Checkpoint InhibitorsIBA 03/2014
1	SmokeIBA 10/2013
1	Messenger RNA (mRNA)IBA 10/2013

Therapy/Procedure

6	Therapeutics 01/2020 - 04/2004
2	Controlled Hypotension 10/2015 - 09/2010
2	Ligation 09/2014 - 08/2009
2	Cardiopulmonary Resuscitation (CPR) 10/2011 - 01/2009
1	Renal Dialysis (Hemodialysis) 01/2015
1	Punctures 09/2014